HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 7-methoxy-5-((1-methylpiperidin-4-yl)oxy)quinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 7-methoxy-5-(N-methylpiperidin-4-yloxy)-3-pivaloyloxymethyl-3,4-dihydroquinazolin-4-one | HCID 11973902 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-methoxy-5-((1-methylpiperidin-4-yl)oxy)quinazolin-4(3H)-one | HCID 135510699 | 75.1% |
Reaction Steps
7.0 N ammonia in methanol (25 ml) was added to (7-methoxy-5-((1-methylpiperidin-4-yl)oxy)-4-oxoquinazolin-3(4H)-yl)methyl pivalate (370 mg, 0.92 mmol) and the solution stirred at ambient temperature for 18 hours. The reaction mixture was concentrated in vacuo to give an oil which was triturated with diethyl ether to give an orange solid which was collected by suction filtration and dried in vacuo to yield 7-methoxy-5-((1-methylpiperidin-4-yl)oxy)quinazolin-4(3H)-one (200 mg, 75% yield):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402585B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-cdd18f06ff2444b48d0bfc621990b6d3 |
| Source note | uspto-grants-2008_07 |