HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethanol → 5,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | Diglyme | HCID 8150 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 5,7-Difluoro-3,4-dihydroquinazolin-4-one | HCID 135510687 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 5,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one | HCID 136351953 | 99% |
Reaction Steps
5,7-difluoroquinazolin-4(3H)one (728 mg, 4 mmol) in diglyme (15 ml) and potassium tert-butoxide (4.48 g, 32 mmol) were reacted with 2-methoxyethanol (2.52 ml, 32 mmol) at 110° C. for 1 hour. The mixture was cooled and purified by chromatography on silica gel. Elution with dichloromethane:methanol (96:4) then increased polarity to dichloromethane:methanolic ammonia (95:5) yielded 5,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one (982 mg, 99% yield):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402585B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f9689fa1239d4bc69a517f720e3ce9d1 |
| Source note | uspto-grants-2008_07 |