HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 749194Generated: November 2, 2026
2-Methoxyethanol → 5-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one
https://huagongshe.com/reaction/749194
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methoxyethanol | HCID 8019 | — |
| Reactant | 7-Fluoro-5-isopropoxy-3,4-dihydroquinazolin-4-one | HCID 136231400 | — |
| Product | 5-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one | HCID 136351954 | 28% |
Reaction Steps
An analogous reaction to that described in example 137b, but starting with 7-fluoro-5-isopropoxyquinazolin-4(3H)-one (444 mg, 2 mmol) and 2-methoxyethanol (0.32 ml, 4.06 mmol) and heating at 120° C. for 1.5 hours yielded 5-isopropoxy-7-(2-methoxyethoxy)quinazolin-4(3H)-one (155 mg, 28% yield) as a beige solid:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07402585B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-f35f3f79f0dd45b1aecbaba59075073f |
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| Source note | uspto-grants-2008_07 |
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