HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178522051, compound → 3-amino-N-(3-fluorophenyl)-1H-pyrazole-5-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178522051 | HCID 178522051 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 3-amino-N-(3-fluorophenyl)-1H-pyrazole-5-carboxamide | HCID 64523814 | 73.8% |
Reaction Steps
N-(3-fluorophenyl)-3-nitro-1H-pyrazole-5-carboxamide (100 mg, 0.4 mmol) in ethyl acetate:ethanol (10:4) was stirred with platinum dioxide (10 mg) under an atmosphere of hydrogen (70 psi) for 3 hours. The catalyst was filtered off and the solvent was evaporated in vacuo to yield 3-amino-N-(3-fluorophenyl)-1H-pyrazole-5-carboxamide (65 mg, 73% yield):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402585B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-1a744f5b481b43af84f799777fb6483d |
| Source note | uspto-grants-2008_07 |