HCID 86597791, compound → HCID 86597792, compound

HRID 749208Notes

Reaction equation

HRID 749208 reaction equation
[CH2:1]([O:3][C:4](=[O:37])[CH2:5][O:6][C:7]1[CH:33]=[CH:32][C:10]2[C:11]([CH2:14][CH2:15][C:16]3[N:17]=[C:18]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=4[Cl:31])[O:19][C:20]=3[CH:21]([CH3:23])[CH3:22])=[N:12][O:13][C:9]=2[C:8]=1[CH2:34][CH:35]=[CH2:36])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:37])[CH2:5][O:6][C:7]1[CH:33]=[CH:32][C:10]2[C:11]([CH2:14][CH2:15][C:16]3[N:17]=[C:18]([C:24]4[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=4[Cl:31])[O:19][C:20]=3[CH:21]([CH3:22])[CH3:23])=[N:12][O:13][C:9]=2[C:8]=1[CH2:34][CH2:35][CH3:36])[CH3:2]

Participants

4

Reactant 1

HCID 86597791HCID 86597791, compound

Product 1

HCID 86597792HCID 86597792, compoundYield 96.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl[[7-allyl-3-[2-[2-(2,4-dichlorophenyl)-5-isopropyl-4-oxazolyl]ethyl]-1,2-benzisoxazol-6-yl]oxy]acetate (65 mg, 0.12 mmol) was dissolved in ethanol (7. 0 mL). To the solution, 10% Pd-C (6 mg) was added. The mixture was stirred for 3 hours under hydrogen atmosphere (and ordinary pressure). After insoluble was filtered off, the filtrate was condensed to give the desired compound (63 mg) as colorless oil in the residue (yield 97%).

Workup

  1. filtrationAfter insoluble was filtered off
  2. customcondensed

Sources & evidence

ORD record
ord-0ccf869ab0a44decacbe9b09e6779770
Source dataset
uspto-grants-2008_07
Patent number
US07402597B2

Reaction notes

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