2,4-Difluorobenzylamine → 2-adamantan-1-yl-N-[2-(2,4-difluoro-benzyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yl]-acetamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-adamantan-1-yl-N-(1-oxo-isochroman-5-yl)-acetamide (39 mg, 0.115 mmol) and 2,4-difluorobenzylamine (99 mg, 0.689 mmol) was heated at 160° C. for 40 h. The reaction vessel was cooled to room temperature and the solvents removed under reduced pressure. The crude product was purified by prep. HPLC to afford 2-adamantan-1-yl-N-[2-(2,4-difluoro-benzyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yl]-acetamide (19.2 mg, 0.042 mmol, 36%) as a white solid.

Provenance & Evidence