反应详情

温度

80 °C

3-[4-(6-Bromo-hexyloxy)-butyl]benzenesulfonamide (1.0 g) in toluene (4 ml) was added dropwise to benzylamine (0.65 g) and the resulting mixture heated at 80° C. for 6 h. The mixture was then cooled and 20% aqueous sodium hydroxide solution (50 ml) was added. The resulting mixture was extracted with ethyl acetate and the combined organic layers evaporated to dryness in vacuo. The residual oil was then purified by chromatography (DCM-IMS-NH3(aq) 100:10:1) to give the title compound (0.54 g) LC RT=3.89 min.

1. temperatureThe mixture was then cooled
2. extractionThe resulting mixture was extracted with ethyl acetate
3. customthe combined organic layers evaporated to dryness in vacuo
4. customThe residual oil was then purified by chromatography (DCM-IMS-NH3(aq) 100:10:1)