Tetrahydrofuran → N-[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]piperidine-4-carboxamide bishydrochloride

関与物質

役割	名称	HCID	仕込み量
反応物	Tetrahydrofuran	HCID 8028	—
反応物	Diisopropylethylamine	HCID 81531	—
反応物	1,2-Diaminocyclohexane, (+)-	HCID 479307	—
反応物	5-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine	HCID 57597747	—
反応物	5-Chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine	HCID 67285321	—
生成物	N-[(1R,3S)-3-[[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-pyrimidin-4-yl]amino]cyclohexyl]piperidine-4-carboxamide bishydrochloride	HCID 86762725	—

(1S,2S)-cyclohexane-1,2-diamine, THF, 120° C. microwave (b) methyl-chloroformate, iPr2NEt, CH2Cl2 (c) LiAlH4, THF.