HCID 45356919, compound → HCID 52912190, compound

HRID 749399Notes

Reaction equation

HRID 749399 reaction equation
[CH3:1][C@H:2]1[C@H:31]([CH3:32])[C@@H:30]2[C@@:5]([C:34]([O:36][C@@H:37]3[O:42][C@H:41]([CH2:43][O:44][C@@H:45]4[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([O:53][C@@H:54]5[O:59][C@@H:58]([CH3:60])[C@H:57]([OH:61])[C@@H:56]([OH:62])[C@H:55]5[OH:63])[C@H:47]([OH:64])[C@H:46]4[OH:65])[C@@H:40]([OH:66])[C@H:39]([OH:67])[C@H:38]3[OH:68])=[O:35])([CH2:6][CH2:7][C@:8]3([CH3:33])[C@:13]4([CH3:29])[CH2:14][C@@H:15](O)[C@H:16]5[C@@:21]([CH2:23][OH:24])([CH3:22])[C@@H:20]([OH:25])[C@H:19]([OH:26])[CH2:18][C@:17]5([CH3:27])[C@H:12]4[CH2:11][CH:10]=[C:9]32)[CH2:4][CH2:3]1>C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC([C@]45CCC(C)(C)C[C@H]4C4=CC[C@@H]6[C@@]7(C)C[C@@H](O)[C@H](O)[C@](CO)(C)[C@@H]7[C@H](O)C[C@@]6(C)[C@]4(C)CC5)=O)C(O)[C@@H](O)C3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O>[CH3:1][C@H:2]1[C@H:31]([CH3:32])[C@@H:30]2[C@@:5]([C:34]([O:36][C@@H:37]3[O:42][C@H:41]([CH2:43][O:44][C@@H:45]4[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([O:53][C@@H:54]5[O:59][C@H:58]([CH3:60])[C@H:57]([OH:61])[C@@H:56]([OH:62])[C@H:55]5[OH:63])[C@H:47]([OH:64])[C@H:46]4[OH:65])[C@@H:40]([OH:66])[C@H:39]([OH:67])[C@H:38]3[OH:68])=[O:35])([CH2:6][CH2:7][C@@:8]3([CH3:33])[C@:13]4([CH3:29])[CH2:14][CH2:15][C@H:16]5[C@@:21]([CH2:23][OH:24])([CH3:22])[C@@H:20]([OH:25])[C@H:19]([OH:26])[CH2:18][C@:17]5([CH3:27])[C@H:12]4[CH2:11][CH:10]=[C:9]32)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 45356919HCID 45356919, compound

Product 1

HCID 52912190HCID 52912190, compound

Reagents, catalysts & solvents 1

HCID 72941669HCID 72941669, compoundSolvent

Procedure

The solution thus obtained is filtered and then concentrated, in a reactor under reduced pressure, until an aqueous phase is obtained, according to the same principle as the preceding concentration. It is then readjusted by adding ethanol in order to obtain a stabilized aqueous-alcoholic solution having a solids content of 200 g +/−20 per liter and an alcohol percentage of 35%+/−3.5% volume/volume. A prepurified phase rich in madecassoside and in terminoloside and still containing asiaticoside is thus obtained.

Workup

  1. customThe solution thus obtained
  2. filtrationis filtered
  3. concentrationconcentrated, in a reactor under reduced pressure, until an aqueous phase
  4. customis obtained
  5. concentrationaccording to the same principle as the preceding concentration
  6. additionby adding ethanol in order
  7. customto obtain a stabilized aqueous-alcoholic solution

Sources & evidence

ORD record
ord-74134c49c251431a9754c61988ad9fd8
Source dataset
uspto-grants-2008_07
Patent number
US07402669B2

Reaction notes

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