Potassium Carbonate → HCID 10597140, compound

Participants

Reaction Steps

The compound prepared as in Example 4 undergoes a substitution reaction with naphthalene-1-sulfonyl chloride (2 equiv) in diisopropylethylamine and CH2Cl2 to generate 2-(2-chloro-ethyl)-1-(naphthalene-1-sulfonyl)-piperidine. Displacement of the chloro substituent with 4-methylpiperidine with sodium iodide as catalyst in the presence of K2CO3 and CH3CN generates the title compound, a reported 5-HT7 receptor modulator (see, for example, Lovell, P. J., Bromidge, S. M., Dabbs, S., Duckworth, D. M., Forbes, I. T., Jennings, A. J., King, F. D., Middlemiss, D. N.; Rahman, S. K., Saunders, D. V., Collin, L. L., Hagan, J. J., Riley, G. J., Thomas, D. R., J. Med. Chem. 2000, 43, 342-345).

Provenance & Evidence