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HRID749429

反应详情

EQUATION

反应方程式

HRID 749429 的结构方程式

REACTANTS

反应物

2
结构：CN(CC(CCN1CC(N2CCSCC2)C1)c1ccc(F)cc1)C(=O)OC(C)(C)C
HCID86606882

未命名化合物

结构：CN(C[C@@H](CCN1CC(N2CCC(O)CC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)OC(C)(C)C
HCID86606883

未命名化合物

PRODUCTS

生成物

1
结构：CNC[C@@H](CCN1CC(N2CCC(O)CC2)C1)c1ccc(Cl)c(Cl)c1.Cl.Cl
HCID68976792

未命名化合物

PROCEDURE

实验过程

The compound was synthesized in an analogous way to that of Method 3e but using tert-butyl {(2S)-2-(3,4-dichlorophenyl)-4-[3-(4-hydroxypiperidin-1-yl)azetidin-1-yl]butyl}methylcarbamate rather than tert-butyl [2-(4-fluorophenyl)-4-(3-thiomorpholin-4-ylazetidin-1-yl)butyl]methylcarbamate (yield, 100%). 1H NMR (500 MHz, CD3OD): 1.8-2.2 (m, 6H), 2.7 (s, 3H), 3.2-4.8 (cm, 17H), 7.4 (dd, 1H), 7.6-7.7 (m, 2H), LCMS: m/z 387 (M+1)+.

WORKUP

后处理

  1. customThe compound was synthesized in an analogous way to that of Method 3e