HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-dibromo-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide → 3,5-dibromo-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-dibromo-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide | HCID 68976787 | — |
| Reactant | N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86606886 | — |
| Product | 3,5-dibromo-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methylbenzamide | HCID 58683530 | — |
Reaction Steps
The compound was synthesized in an analogous way to that of Method 20b but using 3,5-dibromo-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide rather than N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methyl-3,5-bis(trifluoromethyl)benzamide (yield, 96%). 1H NMR (400 MHz, CDCl3): 2.6-3.9 (cm, 8H), 6.8-8.2 (cm, 7H), 9.8 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402581B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-5d88cff8c309411e9acb19d58c929e0f |
| Source note | uspto-grants-2008_07 |