Water → HCID 68979664, compound

Participants

Reaction Steps

A mixture of methyl 3-fluoro-5,6,7,8-tetrahydronaphthalene-1-carboxylate (37 mg, 0.18 mmol), LiOH (27 mg, 1.1 mmol), water (2 mL) and THF (1 mL) was stirred at room temperature overnight and then partitioned between ether and water. The aqueous layer was extracted thrice with ether and then repeatedly with ethyl acetate. The combined organic solutions were dried over MgSO4 and the solvent was removed by evaporation. There was obtained 15 mg (43%) of 3-fluoro-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid as a white solid. 1H NMR (500 MHz, CD3CO CD3): 1.8 (m, 4H), 2.8 (m, 2H), 3.1 (m, 2H), 7.0 (m, 1H), 7.6 (m, 1H).

Provenance & Evidence