HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 749484Generated: October 25, 2026
Sulfuric Acid → 2,4-Dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoic acid
https://huagongshe.com/reaction/749484
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ethyl 2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoate | HCID 69305912 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,4-Dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoic acid | HCID 68798267 | 89.7% |
Reaction Steps
120 mg (0.31 mmol) of ethyl 2,4-dichloro-5-(2-chloro-4,6-difluorophenylamino)benzoate were suspended in 6 ml of an ethanol/2 N sodium hydroxide solution mixture (1:1) and heated at 90° C. for 3 hours. After cooling to room temperature, the pH was adjusted to 2 with 2 N sulfuric acid, and the precipitate was filtered off with suction. 98 mg (88%) of the product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07402674B2 |
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| Source dataset | uspto-grants-2008_07 |
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| ORD ID | ord-02347f89e7ff45a3bdaa4e3d85527075 |
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| Source note | uspto-grants-2008_07 |
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