HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-[4-(Bromomethyl)phenyl]ethan-1-one | HCID 583785 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235039 | 79% |
Reaction Steps
Using 0.3 g of (3,3,3-trifluoropropyl)malononitrile, 3 ml of N,N-dimethylformamide, 0.08 g of sodium hydride (60% in oil), and 0.4 g of 4-acetylbenzyl bromide, and according to the process described in the Production Example 1, there was obtained 0.43 g of 2-(4-acetylbenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (6)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b959e0b912e0481d9446d9479abfd2e8 |
| Source note | uspto-grants-2008_07 |