HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((4-Chlorophenyl)methyl)propanedinitrile → 2-(4-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((4-Chlorophenyl)methyl)propanedinitrile | HCID 18082 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22234970 | 22% |
Reaction Steps
Using 1.00 g of (4-chlorobenzyl)malononitrile, 10 ml of N,N-dimethylformamide, 1.0 g of sodium hydride (60% in oil), and :0.93 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.21 g of 2-(4-chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (15)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-3275d3997d7d4f44a7061f72f4aaba53 |
| Source note | uspto-grants-2008_07 |