HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(3,4-Dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| Reactant | HCID 12194483 | HCID 12194483 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3,4-Dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235032 | 45% |
Reaction Steps
Using 2.00 g of (3,4-dichlorobenzyl)malononitrile, 20 ml of N,N-dimethylformamide, 0.36 g of sodium hydride (60% in oil), and 2.37 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.42 g of 2-(3,4-dichlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (21)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-844f921be8644fd7a7663208271906d9 |
| Source note | uspto-grants-2008_07 |