HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroethyl bromide → 2-(2-Fluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroethyl bromide | HCID 12982 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (4-(Trifluoromethyl)benzyl)malononitrile | HCID 10656743 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2-Fluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile | HCID 22235034 | 48% |
Reaction Steps
Using 0.23 g of (4-(trifluoromethyl)benzyl)malononitrile, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.13 g of 1-bromo-2-fluoroethane, and according to the process described in the Production Example 1, there was obtained 0.12 g of 2-(2-fluoroethyl)-2-(4-(trifluoromethyl)benzyl)malononitrile (the present compound (64)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-db806d698f68426393c95990c9406cf8 |
| Source note | uspto-grants-2008_07 |