HuagongsheHuagongshe Chemistry Print Report · For research reference only
m,alpha-Dichlorotoluene → 2-(3-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m,alpha-Dichlorotoluene | HCID 12103 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(3,3,3-Trifluoropropyl)malononitrile | HCID 22185761 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-Chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235068 | 42.1% |
Reaction Steps
Using 0.16 g of 3-chlorobenzyl chloride, 3 ml of N,N-dimethylformamide, 0.05 g of sodium hydride (60% in oil), and 0.17 g of (3,3,3-trifluoropropyl)malononitrile, and according to the process described in the Production Example 26, there was obtained 0.12 g of 2-(3-chlorobenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (82)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-0ce4828994784070a097f3469edac7d5 |
| Source note | uspto-grants-2008_07 |