HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 2-(3-(Benzyloxy)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| Reactant | (3-Benzyloxybenzyl)malononitrile | HCID 22235026 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-(Benzyloxy)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22234988 | 40.7% |
Reaction Steps
Using 0.52 g of (3-benzyloxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.28 g of 2-(3-(benzyloxy)benzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (88)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402691B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-31fe4c15bce54e388b700eb4260729b5 |
| Source note | uspto-grants-2008_07 |