Sodium borohydride → HCID 22234966, compound

HRID 749614Notes

Reaction equation

HRID 749614 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH:4]=[C:5]([C:8]#[N:9])[C:6]#[N:7].[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:3]=1[CH2:4][CH:5]([C:6]#[N:7])[C:8]#[N:9]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22235080HCID 22235080, compound

Product 1

HCID 22234966HCID 22234966, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using 10.0 g of (2-chloro-4-fluorobenzyliden)malononitrile, 200 ml of ethanol and 0.6 g of sodium borohydride, and according to the process described in the Reference Production Example 3, there was obtained 0.55 g of (2-chloro-4-fluorobenzyl)malononitrile (the intermediate (24)).

Sources & evidence

ORD record
ord-3281be40bb4b481ebc9f464015aca06c
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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