Ethanol → HCID 22235010, compound

HRID 749616Notes

Reaction equation

HRID 749616 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11](#[N:15])[CH2:12][C:13]#[N:14].C(O)C.[BH4-].[Na+]>O>[F:1][C:2]1[CH:9]=[C:8]([Br:10])[CH:7]=[CH:6][C:3]=1[CH2:4][CH:12]([C:11]#[N:15])[C:13]#[N:14]

Participants

6

Reactant 4

HCID 702EthanolHCID 8010MalononitrileHCID 1435174-Bromo-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

Product 1

HCID 22235010HCID 22235010, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Using 1.02 g of 2-fluoro-4-bromobenzaldehyde, 0.33 g of malononitrile, 8 ml of ethanol, 1.5 ml of water and 57 mg of sodium borohydride, and according to the process described in the Reference Production Example 19, there was obtained 1.21 g of (2-fluoro-4-bromobenzyl)malononitrile (the intermediate (29)).

Sources & evidence

ORD record
ord-1c4311a2ab774f298e65a88519150b16
Source dataset
uspto-grants-2008_07
Patent number
US07402691B2

Reaction notes

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