Diisopropylethylamine → (2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-7,7-dimethylazepan-2-one

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	HOAt	HCID 181649	—
Reactant	3-Amino-1-methylpyrrolidin-2-one	HCID 45791133	—
Reactant	5-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine	HCID 57597747	—
Reactant	5-Chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine	HCID 67285321	—
Solvent	Tetrahydrofuran	HCID 8028	—
Solvent	Dimethylacetamide	HCID 31374	—
Solvent	dichloromethane N,N-dimethylformamide	HCID 22350042	—
Product	(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)-7,7-dimethylazepan-2-one	HCID 131731864	—

3-amino-1-methylpyrrolidin-2-one, DMA, 140° C. microwave; (b) LiOH, THF, microwave, 120° C. (c) EDCI, HOAt, iPr2NEt, DCM-DMF (2:1).