Tetramethyl cyclobutane-1,2,3,4-tetracarboxylatato(2-) → 1,2,3,4-Cyclobutanetetracarboxylic Acid

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Reaction Steps

The resultant tetramethyl cyclobutane-1,2,3,4-tetracarboxylate (1224 g, 4.25 mol) and aqueous hydrochloric acid (3000 ml) were added to a 5-liter flask; reacted at a controlled temperature of 85° C. for 24 hours; cooled to room temperature; concentrated; and dried to obtain cyclobutane-1,2,3,4-tetracarboxylic acid (870 g, 3.75 mol).

Provenance & Evidence