Aniline → Acetanilide

Participants

Reaction Steps

For example, diarylamines may be produced using traditional Goldberg reactions. This method requires the derivatization of an aniline with acetic anhydride to produce an acetanilide compound. The acetanilide compound is then reacted with an arylbromide compound to produce an intermediate that must then be hydrolyzed in alcohol solution to produce the diarylamine compound. Total cycle time for this process can be 3 to 5 days in the lab.

Provenance & Evidence