Triethylamine → 2-[(2-Chloroethoxy)methoxy]adamantane

Participants

Reaction Steps

A two neck Kjeldahl flask of 50 ml into which a stirrer was put was charged with 1.55 g (12 mmol) of 2-chloroethyl chloromethyl ether obtained in Example 1 (1), 1.52 g (10 mmol) of 2-adamantanol, 1.52 g (15 mmol) of triethylamine and dried THF, and it was equipped with a coiled condenser to reflux and stir the solution for 8 hours. Triethylamine hydrochloride was filtered, and gas chromatographic analysis was carried out to find that 2-adamantanol was converted by 97.6% and that 2.35 g (9.6 mmol, isolation yield: 96.2%) of a colorless liquid which was the intended product was obtained at a selectivity of 98.6%.

Provenance & Evidence