N-benzyl-2-(3,4-dichlorophenyl)-2-(1-hydroxycyclohexyl)acetamide → HCID 11560688, compound

HRID 749665Notes

Reaction equation

HRID 749665 reaction equation
Cl.[Cl:2]C1C=C(C(C2(O)CCN(C)CC2)CN2CCNCC2)C=CC=1Cl.[CH2:26]([NH:33][C:34](=O)[CH:35]([C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[C:45]([Cl:50])[CH:44]=1)[C:36]1([OH:42])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[ClH:2].[CH2:26]([NH:33][CH2:34][CH:35]([C:36]1([OH:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41]1)[C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[C:45]([Cl:50])[CH:44]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 68852233N-benzyl-2-(3,4-dichlorophenyl)-2-(1-hydroxycyclohexyl)acetamideHCID 68852918HCID 68852918, compound

Product 1

HCID 11560688HCID 11560688, compound

Procedure

In an analogous manner to Example 1, step 2 4-[1-(3,4-dichlorophenyl)-2-piperazin-1-ylethyl]-1-methylpiperidin-4-ol hydrochloride was prepared from N-benzyl-2-(3,4-dichlorophenyl)-2-(1-hydroxycyclohexyl)acetamide. HRMS: calcd for C21H25Cl2NO.HCl, 413.1080; found (ESI_FT), 378.13864.

Sources & evidence

ORD record
ord-20128fe9464f43cb805199ec15d76a7a
Source dataset
uspto-grants-2008_07
Patent number
US07402698B2

Reaction notes

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