HCID 68851985, compound → HCID 68856182, compound

HRID 749690Notes

Reaction equation

HRID 749690 reaction equation
[ClH:1].Cl.F[C:4]1C=CC(CCOC2C=CC(C3(O)CCCCC3CCN3CCN(C)CC3)=CC=2)=CC=1.Cl.Cl.[F:37][C:38]1[CH:43]=[CH:42][C:41]([CH2:44][CH2:45][O:46][C:47]2[CH:52]=[CH:51][C:50]([CH:53]([C:61]3([OH:67])[CH2:66][CH2:65][CH2:64][CH2:63][CH2:62]3)[CH2:54][N:55]3[CH2:60][CH2:59][NH:58][CH2:57][CH2:56]3)=[CH:49][CH:48]=2)=[CH:40][CH:39]=1>>[ClH:1].[ClH:1].[F:37][C:38]1[CH:39]=[CH:40][C:41]([CH2:44][CH2:45][O:46][C:47]2[CH:48]=[CH:49][C:50]([CH:53]([C:61]3([OH:67])[CH2:62][CH2:63][CH2:64][CH2:65][CH2:66]3)[CH2:54][N:55]3[CH2:60][CH2:59][N:58]([CH3:4])[CH2:57][CH2:56]3)=[CH:51][CH:52]=2)=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 68851985HCID 68851985, compoundHCID 86601093HCID 86601093, compound

Product 1

HCID 68856182HCID 68856182, compound

Procedure

In an analogous manner to Example 24, 1-[1-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2-(4-methylpiperazin-1-yl)ethylcyclohexanol dihydrochloride was prepared from 1-(1-{4-[2-(4-fluorophenyl)ethoxy]phenyl}-2-piperazin-1-ylethyl)cyclohexanol (see Example 462). MS (ESI) m/z 441.

Sources & evidence

ORD record
ord-d012e9343b7747f6a62e937fdc61109f
Source dataset
uspto-grants-2008_07
Patent number
US07402698B2

Reaction notes

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