Benzylamine → HCID 11278059, compound

HRID 749709Notes

Reaction equation

HRID 749709 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([CH:30]=[CH:31][N+]([O-])=O)=[CH:26][CH:25]=1>>[CH2:15]([N:22]1[C:11]2[CH2:10][CH2:9][NH:8][CH2:13][C:12]=2[C:30]([C:27]2[CH:28]=[CH:29][C:24]([CH3:23])=[CH:25][CH:26]=2)=[CH:31]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 2867351-Methyl-4-(2-nitroethenyl)benzeneHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 11278059HCID 11278059, compound

Procedure

The title compound (89.7 mg) was prepared from 0.51 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 272 μL of benzylamine, and 0.41 g of 1-methyl-4-(2-nitro-vinyl)-benzene. MS (ESI): exact mass calculated for C21H22N2, 302.18; found, m/z 303.2 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.35-7.31 (m, 2H), 7.29-7.25 (m, 1H), 7.23-7.20 (m, 2H), 7.18-7.14 (m, 4H), 7.06 (s, 1H), 5.13 (s, 2H), 4.33 (s, 2H), 3.49 (t, J=6.3 Hz, 2H), 2.86 (t, J=6.3 Hz, 2H).

Sources & evidence

ORD record
ord-c6cc0f9a0f4c493b97092f9fc5c5f9ab
Source dataset
uspto-grants-2008_07
Patent number
US07402680B2

Reaction notes

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