Benzylamine → HCID 59752665, compound

HRID 749711Notes

Reaction equation

HRID 749711 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[N+]([CH:26]=[CH:27][C:28]1[CH:36]=[CH:35][C:31]2[O:32][CH2:33][O:34][C:30]=2[CH:29]=1)([O-])=O>>[O:32]1[C:31]2[CH:35]=[CH:36][C:28]([C:27]3[C:12]4[CH2:13][NH:8][CH2:9][CH2:10][C:11]=4[N:22]([CH2:15][C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:26]=3)=[CH:29][C:30]=2[O:34][CH2:33]1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 949455-(2-Nitroethenyl)-1,3-benzodioxoleHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 59752665HCID 59752665, compound

Procedure

The title compound (306.0 mg) was prepared from 0.49 g of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, 268 μL of benzylamine, and 0.48 g of 5-(2-nitro-vinyl)-benzo[1,3]dioxole. MS (ESI): exact mass calculated for C21H20N2O2, 332.15; found, m/z 333.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 7.36-7.30 (m, 2H), 7.29-7.24 (m, 1H), 7.18-7.14 (m, 2H), 7.01 (s, 1H), 6.85-6.75 (m, 3H), 5.93 (s, 2H), 5.12 (s, 2H), 4.31 (s, 2H), 3.49 (t, J=6.3 Hz, 2H), 2.85 (t, J=6.3 Hz, 2H).

Sources & evidence

ORD record
ord-e50ca565ba5046f484bd7f9edc91a7c5
Source dataset
uspto-grants-2008_07
Patent number
US07402680B2

Reaction notes

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