反应详情

3-chlorobenzenecarboperoxoic acid (2.47 g, 11.00 mmol) was added in one portion to a stirred solution of (R)-tert-butyldimethyl(1-methylcyclohex-2-enyloxy)silane, 50b, (1.98 g, 8.87 mmol) and sodium hydrogen carbonate in 30 mL of dry dichloromethane at room temperature under nitrogen. The resulting mixture was stirred for 20 hours. Then, 25% sodium sulfite solution (30 mL) was added and the resulting biphasic mixture was stirred for 15 minutes. The 2 layers were separated and the aqueous layer was extracted with dichloromethane (2×20 mL). The combined organic phases were washed with aqueous saturated NaHCO3, dried (Na2SO4) and concentrated in vacuo. The crude residue was purified by silica gel chromatography (0-10% EtOAc-hexanes gradient) to provide 647 mg of compound 50c.

1. stirringthe resulting biphasic mixture was stirred for 15 minutes
2. customThe 2 layers were separated
3. extractionthe aqueous layer was extracted with dichloromethane (2×20 mL)
4. washThe combined organic phases were washed with aqueous saturated NaHCO3
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated in vacuo
7. customThe crude residue was purified by silica gel chromatography (0-10% EtOAc-hexanes gradient)