Furan-3-boronic acid → HCID 59752606, 화합물

HRID 749857노트

반응식

HRID 749857 반응식
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:11](=[C:12](OS(C(F)(F)F)(=O)=O)[N:13]([C:18]([CH3:21])([CH3:20])[CH3:19])[N:14]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[O:30]1[CH:34]=[CH:33][C:32](B(O)O)=[CH:31]1>>[C:18]([N:13]1[C:12]([C:32]2[CH:33]=[CH:34][O:30][CH:31]=2)=[C:11]2[C:15]([CH2:16][CH2:17][NH:8][CH2:9][CH2:10]2)=[N:14]1)([CH3:19])([CH3:20])[CH3:21]

참가 물질

3

반응물 2

HCID 2734358Furan-3-boronic acidHCID 86598388HCID 86598388, 화합물

생성물 1

HCID 59752606HCID 59752606, 화합물수율 50.3%

실험 절차

The title compound (60 mg) was prepared according to Example 215 using 203 mg of 2-(tert-butyl)-3-trifluoromethanesulfonyloxy-4,5,7,8-tetrahydro-2H-1,2,6-triaza-azulene-6-carboxylic acid tert-butyl ester (Example 215, Step A) and 154 mg of 3-furanboronic acid. MS (ESI): exact mass calculated for C15H21N3O, 259.17; found, m/z 260.5 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.69-7.68 (m, 1H), 7.61 (br s, 1H), 6.50-6.49 (m, 1H), 3.38-3.36 (m, 2H), 3.27-3.25 (m, 2H), 3.13-3.11 (m, 2H), 2.63-2.61 (m, 2H), 1.50 (s, 9H).

출처 및 근거

ORD 기록
ord-1e00d8d161f84619a637c69fe33a5528
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07402680B2

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