Thiophene-3-boronic acid → HCID 59752631, compound

HRID 749903Notes

Reaction equation

HRID 749903 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2=[C:14](OS(C(F)(F)F)(=O)=O)[N:15]([CH:17]([CH3:19])[CH3:18])[N:16]=[C:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:28]1[CH:32]=[CH:31][C:30](B(O)O)=[CH:29]1>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]2=[C:14]([C:30]3[CH:31]=[CH:32][S:28][CH:29]=3)[N:15]([CH:17]([CH3:18])[CH3:19])[N:16]=[C:10]2[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 86598393HCID 86598393, compound

Product 1

HCID 59752631HCID 59752631, compoundYield 27.5%

Procedure

The title compound (69 mg) was prepared according to Example 287 using 300 mg of trifluoro-methanesulfonic acid 6-benzyl-2-isopropyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridin-3-yl ester and 133 mg of 3-thiopheneboronic acid. MS (ESI): exact mass calculated for C20H23N3S, 337.16; found, m/z 338.5 [M+H]+. 1H NMR (500 MHz, CD3OD): 7.66-7.65 (m, 1H), 7.60-7.57(m, 3H), 7.55-7.53 (m, 3H), 7.21-7.20 (m, 1H), 4.65-4.52 (m, 3H), 4.42-4.33 (m, 2H), 3.82-3.79 (m, 1H), 3.44-3.40 (m, 1H), 2.94-2.91 (m, 2H), 1.46-1.35 (m, 6H).

Sources & evidence

ORD record
ord-006f106deeb343889bd0311d51ac27c2
Source dataset
uspto-grants-2008_07
Patent number
US07402680B2

Reaction notes

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