関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Bromobiphenyl | HCID 7101 | — |
| 反応物 | 4-Methoxyphenol | HCID 9015 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 触媒 | N,N-Dimethylglycine hydrochloride | HCID 75605 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-(4-Methoxyphenoxy)biphenyl | HCID 266864 | 128.3% |
反応手順
To a solution of 4-bromobiphenyl (1.00 g, 4.29 mmol), 4-methoxyphenol (0.35 g, 2.82 mmol) and cesium carbonate (1.85 g, 5.68 mmol) in dioxane (10 mL) was added N,N-dimethylglycine hydrochloride (0.04 g, 0.26 mmol). The vessel was purged with nitrogen before Cu(I) iodide (0.02 g, 0.11 mmol) was added. The reaction mixture was heated to 90° C. overnight. The reaction mixture was diluted with water and ethyl acetate. The organic portion was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound (1.00 g, 100%) as a light green solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07402684B2 |
|---|
| 出典データセット | uspto-grants-2008_07 |
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| ORD ID | ord-5a55b5283e64482b93abba784c1ebb24 |
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| 出典メモ | uspto-grants-2008_07 |
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