Hydrochloric Acid → HCID 44818808, compound

Participants

Reaction Steps

To the product from step 3 (0.36 g, 0.89 mmol) was added 4 M HCl in dioxane (5 mL). The resulting mixture was stirred at ambient temperature for 2 h. The solvent was removed in vacuo. The crude product was triturated with ether and dried under reduced pressure to afford the title compound (0.19 g, 70%) as a light yellow solid; 1H NMR (400 MHz, DMSO-d6) 1.75 (m, 1H), 1.87-2.01 (m, 2H), 2.12 (m, 1H), 3.21 (m, 2H), 3.89 (m, 1H), 4.17 (m, 1H), 4.24 (dd, J1=4.0 Hz, J2=10.8 Hz, 1H), 6.94 (d, J=9.2 Hz, 2H), 7.05 (s, 4H), 7.40 (d, J=8.8 Hz, 2H); MS (m/z) 304.2 (M+1); LC (97.1%);

Provenance & Evidence