Hydrochloric Acid → HCID 69002049, compound

Participants

Reaction Steps

Following the general procedure for Example 13 (step 4), the product from step 3 (0.39 g, 1.02 mmol) was treated with 4M HCl in dioxane (6 mL) to afford the title compound (0.12 g, 67%) as an off-white solid; 1H NMR (400 MHz, DMSO-d6) 1.74 (m, 1H), 1.94 (m, 2H), 2.11 (m, 1H), 2.27 (s, 3H), 3.21 (m, 2H), 3.88 (m, 1H), 4.13 (m, 1H), 4.22 (dd, J1=3.8 Hz, J2=10.8 Hz, 1H), 6.83 (d, J=8.4 Hz, 2H), 6.98 (m, 4H), 7.16 (d, J=8.4 Hz, 2H), 9.11 (br s, 1H), 9.67 (br s, 1H); MS (m/z) 284.4 (M+1); LC (98.8%); HPLC (99.3%).

Provenance & Evidence