HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2R)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 44819168 | HCID 44819168 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (2R)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]pyrrolidine | HCID 42641832 | 94.6% |
Reaction Steps
Following the general procedure for Example 11 (step 4), the product from step 3 (3.60 g, 8.91 mmol) was treated with 4M HCl in dioxane (6 mL) to afford the title compound (2.56 g, 84%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402684B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-00e6cbee72d34912ba2fdf2f61738d26 |
| Source note | uspto-grants-2008_07 |