Hydrochloric Acid → HCID 59752864, compound

Participants

Reaction Steps

To the product from step 1 (340 mg, 0.927 mmol) was added 4M HCl in dioxane (6 mL) and the resulting mixture was stirred at rt for 3 h. The solvent was removed in vacuo to obtain the title product as a white solid (264 mg, 84%). The solid was dried under vacuum oven at 50° C. for 15 h: MS; m/z 267 (M+H); LCMS (UV) 99%: HPLC 98.8%. 1H NMR (400 MHz, DMSO-d6) δ 1.61-1.66 (m, 1H), 1.84-1.94 (m, 2H), 2.04-2.09 (m, 1H), 3.13-3.18 (m, 2H), 3.30-3.37 (m, 2H), 3.57 (s, 1H), 3.62-3.67 (m, 1H), 3.79 (s, 2H), 6.63 (d, 2H, J=8.4 Hz), 7.0 (d, 2H, J=8.4 Hz), 7.13-7.19 (m, 3H), 7.24-7.28 (m, 2H), 8.9 (s, 1H), 9.4 (s, 1H).

Provenance & Evidence