Boron tribromide → 4-(Oxazol-2-yl)phenol

HRID 750089Notes

Reaction equation

HRID 750089 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][CH:11]=[CH:12][N:13]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>>[O:10]1[CH:11]=[CH:12][N:13]=[C:9]1[C:6]1[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 149317732-(4-Methoxyphenyl)-1,3-oxazole

Product 1

HCID 1356214594-(Oxazol-2-yl)phenolYield 95%

Procedure

The title compound (0.52 g, 95%) was prepared from the product of step 1 (0.6 g, 3.4 mmol) and boron tribromide (1M in methylene chloride, 10.3 ml, 10.3 mmol) using the procedure of Example 146, step 2; 1HNMR (400 MHz, DMSO-d6) δ 8.1 (s, 1H), 7.81 (d, J=8.8 Hz, 2H), 7.30 (s, 1H), 6.92 (d, J=9.2 Hz, 2H), MS (APCI+) 162 (M+1, 100);

Sources & evidence

ORD record
ord-535501e2142c4174aa25a28cb7620536
Source dataset
uspto-grants-2008_07
Patent number
US07402684B2

Reaction notes

Loading…