Hydrochloric Acid → HCID 68998816, compound

Participants

Reaction Steps

The title compound (60 mg, 83%) was prepared from the product of step 1 (0.09 g, 0.21 mmol) and 4M HCl in dioxane (0.5 ml, 2.1 mmol) using the procedure of Example 146, step 4; 1HNMR (400 MHz, CD3OD) δ 9.42 (br, 1H), 8.96 (br, 1H), 7.89 (d, J=3.6 Hz, 1H), 7.86 (d, J=8.4 Hz, 2H), 7.75 (d, J=3.6 Hz, 1H), 7.32 (d, J=8.4 Hz, 2H), 7.20 (d, J=8.8 Hz, 2H), 6.93 (d, J=8.8 Hz, 2H), 4.22 (dd, J=10.4, 3.6 Hz, 1H), 4.08 (m, 1H), 3.96 (s, 2H), 3.89 (m, 1H), 3.20 (m, 2H), 2.12 (m, 1H), 1.92 (m, 2H), 1.63 (m, 1H); LC/MS (APCI+) 99%, 351 (M+1, 100); HPLC 98.5%.

Provenance & Evidence