Hydrochloric Acid → HCID 69001677, compound

Participants

Reaction Steps

The title compound (60 mg, 83%) was prepared from the product of step 1 (0.09 g, 0.21 mmol) and 4M HCl in dioxane (0.5 ml, 2.1 mmol) using the procedure of Example 146, step 4, 1HNMR (400 MHz, CD3OD) δ 8.17 (d, J=4 Hz, 1H), 7.98 (d, J=3.6 Hz, 1H), 7.90 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.4 Hz, 2H), 7.20 (d, J=8.8 Hz, 2H), 6.95 (d, J=8.8 Hz, 2H), 4.32 (dd, J=10.4, 3.6 Hz, 1H), 4.10 (m, 1H), 4.04 (s, 2H), 4.03 (m, 1H), 3.36 (m, 2H), 2.25 (m, 1H), 2.10 (m, 2H), 1.90 (m, 1H); LC/MS (APCI+) 93%, 351 (M+1, 100); HPLC 94%.

Provenance & Evidence