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4-(1,2,4-Triazol-1-yl)phenol → (R)-2-[4-(4-[1,2,4]Triazol-1-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(1,2,4-Triazol-1-yl)phenol | HCID 110064 | — |
| 反応物 | (R)-2-(4-Iodo-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 44819166 | — |
| 生成物 | (R)-2-[4-(4-[1,2,4]Triazol-1-yl-phenoxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 69000404 | 80% |
反応手順
The title compound (130 mg, 80%) was prepared from 4-[1,2,4]triazol-1-yl-phenol (0.7 g, 0.43 mmol) and (R)-2-(4-Iodo-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.23 g, 0.56 mmol) using the procedure of Example 146, step 3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402684B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-7607cac034f646a69d7cddad248a5452 |
| 出典メモ | uspto-grants-2008_07 |