反应详情

To a solution of 6-bromo-4-phenylisocoumarin-3-carboxylic acid (10 g) in methanol (200 ml) was added sulfuric acid (20 ml) and the mixture was refluxed for 2 hrs. The reaction mixture was concentrated, and the residue was neutralized with aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated. The residue was crystallized from isopropyl ether to give the title compound (9.76 g) as colorless crystals.

1. temperaturethe mixture was refluxed for 2 hrs
2. concentrationThe reaction mixture was concentrated
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customThe residue was crystallized from isopropyl ether