反应详情

To the obtained 6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid were added methanol (400 ml) solution and sulfuric acid (40 ml) and the mixture was refluxed for 20 hrs. The reaction mixture was concentrated, and the residue was neutralized with aqueous potassium carbonate solution and extracted with chloroform. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated to give the title compound (6.51 g) as colorless crystals.

1. temperaturethe mixture was refluxed for 20 hrs
2. concentrationThe reaction mixture was concentrated
3. extractionextracted with chloroform
4. washThe organic layer was washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated