Methylhydrazine → 6-chloro-2-methylamino-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

HRID 750127Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:10](=[CH:11][CH:12]=1)[C:8](=O)[O:7][C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH3:22][NH:23][NH2:24]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10](=[CH:11][CH:12]=1)[C:8](=[O:7])[N:24]([NH:23][CH3:22])[C:6]([C:13]([OH:15])=[O:14])=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

Reactant 2

HCID 6061Methylhydrazine

HCID 103800926-chloro-4-phenylisocoumarin-3-carboxylic Acid

Product 1

HCID 230605106-chloro-2-methylamino-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid

Procedure

In the same manner as in Reference Example 6, 6-chloro-4-phenylisocoumarin-3-carboxylic acid and methylhydrazine were reacted to give the title compound.

Sources & evidence

ORD record: ord-b5a74bb8d86b4df9bba4f3bcc67464e3
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07402595B2

Reaction notes

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