Acetic Anhydride → HCID 69155516, compound

Participants

Reaction Steps

To a solution of 6-bromo-1-oxo-4-phenyl-2-(piperidin-4-ylmethyl)-1,2-dihydroisoquinoline-3-carboxylic acid methyl ester hydrochloride (49 mg) in tetrahydrofuran (5 ml) were added triethylamine (0.03 ml) and acetic anhydride (0.05 ml) and the mixture was stirred at room temperature for 16 hrs. The solvent was evaporated under reduced pressure, water was added and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried by adding sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by preparative HPLC to give the title compound (18 mg, 36%).

Provenance & Evidence