Methanol → HCID 69155568, compound

Participants

Reaction Steps

To a solution of 2-(benzo[1,3]dioxol-5-ylmethyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3,6-dicarboxylic acid dimethyl ester (300 mg) in THF (3 ml) were added methanol (3 ml) and 8N-aqueous sodium hydroxide solution (0.16 ml) at room temperature, and the mixture was stirred for 12 hrs. The reaction mixture was concentrated under reduced pressure, and 1N-hydrochloric acid was added to the residue. The aqueous layer of the mixture was acidified, and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was crystallized from ethyl acetate-hexane to give the title compound (230 mg).

Provenance & Evidence