Water → HCID 69156854, compound

Participants

Reaction Steps

2-(2,3-Dihydrobenzofuran-5-ylmethyl)-6-fluoro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (800 mg) was dissolved in DMF (8 ml), and methyl iodide (0.24 ml) and potassium carbonate (530 mg) were added at room temperature. The mixture was stirred for 12 hrs. Water was added to the reaction mixture, and crystals were collected by filtration and washed with water. After drying the crystals, recrystallization (ethyl acetate) gave the title compound (500 mg).

Provenance & Evidence