Water → HCID 69157223, compound

Participants

Reaction Steps

2-Benzyl-6-fluoro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (400 mg) was dissolved in DMF (4 ml) and methyl iodide (0.14 ml) and potassium carbonate (300 mg) were added at room temperature. The mixture was stirred for 12 hrs. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine. The solvent was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue was crystallized from ethyl acetate-hexane to give the title compound (200 mg).

Provenance & Evidence