4-Hydroxymethylpyridine → HCID 69156421, compound

HRID 750207Notes

Reaction equation

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][N:11]3[C:20]([C:21]([OH:23])=[O:22])=[C:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:18]4[C:13](=[CH:14][CH:15]=[C:16]([Br:30])[CH:17]=4)[C:12]3=[O:31])=[CH:9][C:4]=2[O:3][CH2:2]1.[N:32]1[CH:37]=[CH:36][C:35]([CH2:38]O)=[CH:34][CH:33]=1>>[N:32]1[CH:37]=[CH:36][C:35]([CH2:38][O:22][C:21]([C:20]2[N:11]([CH2:10][C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)[C:12](=[O:31])[C:13]3[C:18]([C:19]=2[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:17][C:16]([Br:30])=[CH:15][CH:14]=3)=[O:23])=[CH:34][CH:33]=1

Participants

Reactant 2

HCID 114724-Hydroxymethylpyridine

HCID 23060580HCID 23060580, compound

Product 1

HCID 69156421HCID 69156421, compound

Procedure

The present compound was synthesized by a method similar to that in Example 200 and using 2-(benzo[1,3]dioxol-5-ylmethyl)-6-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid (300 mg) and 4-pyridinemethanol. Colorless crystals (246 mg).

Workup

customThe present compound was synthesized by a method similar to that in Example 200

Sources & evidence

ORD record: ord-94d1d44ef1ae40feaf7164c5eb868477
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07402595B2

Reaction notes

Loading…